@article{Іванова_Фізор_Максименко_2018, title={Using of tranexamic acid as component of trauma induced coagulopathy treatment}, url={https://jpaic.aaukr.org/article/view/151493}, DOI={10.25284/2519-2078.4(85).2018.151493}, abstractNote={<p><strong>The aim</strong> of the study was to determine the effectiveness of tranexamic acid in patients with multiple skeletal trauma for reducing blood loss and correction of hemostatic disorders.</p><p><strong>Materials and methods</strong>. The initial state of the hemostasis system was studied in 104 patients with multiple trauma. All patients was in class II (15-30 % of blood loss) according to ATLS protocol, and NISS – 28,34±2,06. Was provided complex evaluation of patients state, including continuous monitoring of temperature and lactates level, the hemostasis system was evaluated using laboratory tests and low-frequency pyezoelectric thromboelastography (LPTEG). Patients in Group I (n = 33) did not receive tranexamic acid, Patients in Group II received tranexamic acid 15 mg / kg every 6 hours for 3 days.</p><p><strong>Results</strong>. In patients who received tranexamic acid, there was a positive dynamics of hemoglobin, creatinine phosphokinase, lactate, less need for transfusion of blood products and duration of treatment in ICU.</p><p><strong>Conclusions</strong>. The use of antifibrinolytic drugs positively influences the course of traumatic disease in patients with polytrauma, by correcting coagulopathy and reducing blood loss.</p>}, number={4(85)}, journal={PAIN, ANAESTHESIA & INTENSIVE CARE}, author={Іванова, В. О. and Фізор, В. Д. and Максименко, О. В.}, year={2018}, month={Груд}, pages={51–54} }