Using of tranexamic acid as component of trauma induced coagulopathy treatment


  • В. О. Іванова Odessa national medical university, Odesa, Україна
  • В. Д. Фізор Odessa national medical university, Odesa, Україна
  • О. В. Максименко Odessa national medical university, Odesa, Україна


Ключові слова:

trauma, fibrinolysis, tranexamic acid


The aim of the study was to determine the effectiveness of tranexamic acid in patients with multiple skeletal trauma for reducing blood loss and correction of hemostatic disorders.

Materials and methods. The initial state of the hemostasis system was studied in 104 patients with multiple trauma. All patients was in class II (15-30 % of blood loss) according to ATLS protocol, and NISS – 28,34±2,06. Was provided complex evaluation of patients state, including continuous monitoring of temperature and lactates level, the hemostasis system was evaluated using laboratory tests and low-frequency pyezoelectric thromboelastography (LPTEG). Patients in Group I (n = 33) did not receive tranexamic acid, Patients in Group II received tranexamic acid 15 mg / kg every 6 hours for 3 days.

Results. In patients who received tranexamic acid, there was a positive dynamics of hemoglobin, creatinine phosphokinase, lactate, less need for transfusion of blood products and duration of treatment in ICU.

Conclusions. The use of antifibrinolytic drugs positively influences the course of traumatic disease in patients with polytrauma, by correcting coagulopathy and reducing blood loss.

Біографії авторів

В. О. Іванова, Odessa national medical university, Odesa

Иванова В.А.

В. Д. Фізор, Odessa national medical university, Odesa

Private clinic Odrex

О. В. Максименко, Odessa national medical university, Odesa

Private clinic Odrex


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Як цитувати

Іванова, В. О., Фізор, В. Д., & Максименко, О. В. (2018). Using of tranexamic acid as component of trauma induced coagulopathy treatment. PAIN, ANAESTHESIA & INTENSIVE CARE, (4(85), 51–54.



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