ГІПОНАТРІЕМІЯ: ПРИЧИНИ, КЛІНІЧНІ ПРОЯВИ ТА КОРЕКЦІЯ

У. А. Фесенко

doi:10.25284/2519-2078.4(89).2019.187786

Автор(и)

У. А. Фесенко Львівський національний медичний університет імені Данила Галицького, Львів, Україна

DOI:

https://doi.org/10.25284/2519-2078.4(89).2019.187786

Ключові слова:

гіпонатріемія, вазопресин, синдром невідповідної секреції антидіуретичного гормону, синдром втрати солей, ваптани

Анотація

Представлений аналіз літературних джерел з проблеми гіпонатріемії. Описані причинні фактори, клінічні прояви, критерії тяжкості гіпонатріемії. Наведені діагностичні алгоритми для виявлення причини гіпонатріемії на грунті осмолярності плазми, волемічного статусу пацієнта та фракційної екскреції натрію та уратів. Проведений аналіз сучасних гайдлайнів з корекції гіпонатріемії, описані покази та обмеження застосування ваптанів.

Біографія автора

У. А. Фесенко, Львівський національний медичний університет імені Данила Галицького, Львів

Fesenko U.A.

Посилання

Upadhyay A, Jaber BL, Madias NE. Incidence and prevalence of hyponatremia. Am J Med. 2006;119 (7 Suppl 1):S30–S35. PMID: 16843082 DOI: 10.1016/j.amjmed.2006.05.005
| |

Hoorn EJ, Lindemans J, Zietse R. Development of severe hyponatraemia in hospitalized patients: treatment-related risk factors and inadequate management. Nephrol Dial Transplant. 2006;21(1):70–76. PMID: 16141458 DOI: 10.1093/ndt/gfi082
| |

Mannesse CK, Vondeling AM, van Marum RJ, van Solinge WW, Egberts TC, Jansen PA. Prevalence of hyponatremia on geriatric wards compared to other settings over four decades: A systematic review. Ageing Res Rev. 2013;12(1):165–173. PMID: 22588025 DOI: 10.1016/j.arr.2012.04.006
| |

Clayton JA, Le Jeune IR, Hall IP. Severe hyponatraemia in medical in-patients: aetiology, assessment and outcome. QJM. 2006;99(8):505–511. PMID: 16861720 DOI: 10.1093/qjmed/hcl071
| |

Ball SG. How I approach hyponatraemia. Clin Med. (Lond) 2013;13(3):291–295. PMCID: PMC5922676 PMID: 23760706 doi: 10.7861/clinmedicine.13-3-291
| |

Adrogué HJ, Madias NE. The challenge of hyponatremia. J Am Soc Nephrol 2012; 23(7): 1140–1148. PMID: 22626822 DOI: 10.1681/ASN.2012020128
| |

Greenberg A, Verbalis JG, Amin AN, Burst VR, Chiodo JA 3rd , Chiong JR, Dasta JF, Friend KE, Hauptman PJ, Peri A, Sigal SH. Current treatment practice and outcomes. Report of the hyponatremia registry. Kidney Int 2015; 88: 167–177. doi:10.1038/ki.2015.4.
| |

Sterns RH. Disorders of plasma sodium – causes, consequences, and correction. N Engl J Med 2015; 372: 55–65. DOI: 10.1056/NEJMra1404489.
| |

Reynolds RM, Padfield PL, Seckl JR. Disorders of sodium balance. BMJ 2006;332(7543):702–5. PMID: 16565125 PMCID: PMC1410848 DOI: 10.1136/bmj.332.7543.702
| |

Zieg J. Pathophysiology of Hyponatremia in Children. Front. Pediatr. 2017;5:213. doi: 10.3389/fped.2017.00213.
| |

Maesaka JK, Imbriano LJ, Miyawaki N. Application of established pathophysiologic processes brings greater clarity to diagnosis and treatment of hyponatremia. World J Nephrol. 2017,6(2):59-71. DOI: http://dx.doi.org/10.5527/wjn.v6.i2.59.

Chappell MC, Marshall AC, Alzayadneh EM, Shaltout HA, Diz DI. Update on the angiotensin converting enzyme 2-angiotensin (1-7)-MAS receptor axis: fetal programing, sex differences, and intracellular pathways. Front Endocrinol (Lausanne). 2014;4:201. doi:10.3389/fendo.2013.00201.
| |

Fernández-Atucha A, Izagirre A, Fraile-Bermúdez AB, Kortajarena M, Larrinaga G, Martinez-Lage P, Echevarría E, Gil J. Sex differences in the aging pattern of renin–angiotensin system serum peptidases. BMC, 2017;8:5. DOI 10.1186/s13293-017-0128-8.
| |

Mohammed AA. van Kimmenade RR, Richards M, Bayes-Genis A, Pinto Y, Moore SA, Januzzi JL Jr. Hyponatremia, natriuretic peptides, and outcomes in acutely decompensated heart failure: results from the international collaborative of NT-proBNP study. Circ Heart Fail 2010;3(3):354–361. PMID: 20332419 doi: 10.1161/CIRCHEARTFAILURE.109.915280.
| |

Pasantes-Morales H, Cruz-Rangel S. Brain volume regulation: osmolytes and aquaporin perspectives. Neuroscience, 2010;168:871–884. doi:10.1016/j.neuroscience.2009.11.074.
| |

Verbalis JG, Greenberg A, Burst V, Haymann JP, Johannsson G, Peri A, Poch E, Chiodo JA 3rd, Dave J. Diagnosing and treating the syndrome of inappropriate antidiuretic hormone secretion. Am J Med. 2016;129(5):537. e9-537.e23. PMID: 26584969 doi: 10.1016/j.amjmed.2015.11.005.
| |

Mocan M, Ternes LM, Blaga SN. Difficulties in the diagnosis and management of hyponatremia. Clujul Medical, 2016;89(4):464-469. DOI: 10.15386/cjmed-619.
|

Fenske W, Sandner B, Christ-Crain M. A copeptin-based classification of the osmoregulatory defects in the syndrome of inappropriate antidiuresis. Best Pract Res Clin Endocrinol Metab 2016; 30(2): 219–233. PMID: 27156760 DOI: 10.1016/j.beem.2016.02.013
|

Fenske WK, Christ-Crain M, Hörning A, Simet J, Szinnai G, Fassnacht M, Rutishauser J, Bichet DG, Störk S, Allolio B. A copeptin-based classification of the osmoregulatory defects in the syndrome of inappropriate antidiuresis. Journal of the American Society of Nephrology, 2014; 25:2376–2383. doi:10.1681/ASN.2013080895.
|

Park S, Eun LY, Kim JH. Relationship between serum sodium level and coronary artery abnormality in Kawasaki disease. Korean J Pediatr 2017;60(2):38-44. https://doi.org/10.3345/kjp.2017.60.2.38.
|

Mukherjee D, Sinha R, Akhtar MS, Saha AS. Hyponatremic hypertensive syndrome - a retrospective cohort study. World J Nephrol 2017;6(1):41-44. DOI: http://dx.doi.org/10.5527/wjn.v6.i1.41.

Zieg J. Evaluation and management of hyponatraemia in children. Acta Paediatr, 2014; 103(10):1027–34. doi:10.1111/apa.12705.
|

Hew-Butler T, Loi V, Pani A, Rosner MH. Exercise-Associated Hyponatremia: 2017 Update. Front. Med. 2017;4:21. doi: 10.3389/fmed.2017.00021.
|

Hsu YJ, Chiu JS, Lu KC, Chau T, Lin SH. Biochemical and etiological characteristics of acute hyponatremia in the emergency department.J Emerg Med 2005;29(4): 369–374. PMID: 16243191 DOI: 10.1016/j.jemermed.2005.02.014
|

Achinger SG, Arieff AI, Kalantar-Zadeh K, Ayus JC. Desmopressin acetate (DDAVP)-associated hyponatremia and brain dam-age: A case series. Nephrol Dial Transplant 2014;29(12): 2310–2315. PMID: 25107337 DOI: 10.1093/ndt/gfu263
|

Liamis G, Milionis H, Elisaf M: A review of drug-induced hyponatremia. Am J Kidney Dis, 2008; 52(1): 144–153. PMID: 18468754 DOI: 10.1053/j.ajkd.2008.03.004
|

Agarwal R, Emmett M. The post-transurethral resection of prostate syndrome: Therapeutic proposals. Am J Kidney Dis 1994; 24(1): 108–111. PMID: 8023816
|

Ayus JC, Arieff AI. Glycine-induced hypo-osmolar hyponatremia. Arch Intern Med, 1997; 157(2): 223–226. PMID: 9009981
|

Windpesslet M, Schwarz C, Wallner M. “Bowel prep hyponatremia“– a state of acute water intoxication facilitated by low dietary solute intake: case report and literature review. BMC Nephrology (2017) 18:54. DOI 10.1186/s12882-017-0464-2.
|

Hoorn EJ, Zietse R. Diagnosis and Treatment of Hyponatremia: Compilation of the Guidelines. J Am Soc Nephrol. 2017;28(5):1340-1349. doi: 10.1681/ASN.2016101139. PMID: 28174217 PMCID: PMC5407738.
|

Barsony J, Manigrasso MB, Xu Q, Tam H, Verbalis JG. Chronic hyponatremia exacerbates multiple manifestations of senescence in male rats. Age (Dordr) 2013;35(2): 271-288. PMID: 22218780 PMCID: PMC3592950 DOI: 10.1007/s11357-011-9347-9
|

Lavagno C, Milani GP, Uestuener P, Simonetti GD, Casaulta C, Bianchetti MG, Fare PB, Lava SA. Hyponatremia in children with acute respiratory infections: A reappraisal. Pediatr Pulmonol. 2017;7. doi: 10.1002/ppul.23671.
|

Al Shibli A, Abukhater D, Al Kuwaiti N, Noureddin MB, Al Harbi M, Al Kaabi A, Al Kaabi S, Hamie M, Al Amri A, Narchi H. Hyponatraemia and neurological complications in children admitted with bronchiolitis. Paediatr Int Child Health. 2016;36(3):175-80. doi: 10.1080/20469047.2016.1162390.
|

Weismann D, Schneider A, Höybye C. Clinical aspects of symptomatic hyponatremia. Endocrine Connections, 2016; 5, R35–R43. DOI: 10.1530/EC-16-0046.
|

Hillier TA, Abbott RD, Barrett EJ. Hyponatremia: evaluating the correction factor for hyperglycemia. Am J Med. 1999;106(4):399–403. PMID: 10225241
|

Overgaard-Steensen C, Ring T. Clinical review: Practical approach to hyponatraemia and hypernatraemia in critically ill patients. Critical Care, 2013;17:206. http://ccforum.com/content/17/1/206. doi:10.1186/cc11805.
|

De Vecchisa R, Noutsias M, Ariano C, Cesaro A, Cioppaa C, Giasi A, Maurea N. Does Accidental Overcorrection of Symptomatic Hyponatremia in Chronic Heart Failure Require Specific Therapeutic Adjustments for Preventing Central Pontine Myelinolysis? J Clin Med Res. 2017;9(4):266-272. doi: https://doi.org/10.14740/jocmr2933w.

Ismail FY, Szóllics A, Szólics M, Nagelkerke N, Ljubisavljevic M. Clinical semiology and neuroradiologic correlates of acute hypernatremic osmotic challenge in adults: a literature review. Am J Neuroradiol 2013; 34(12): 2225-2232. DOI: https://doi.org/10.3174/ajnr.A3392
|

Soupart A, Penninckx R, Namias B, Stenuit A, Perier O, Decaux G. Brain myelinolysis following hypernatremia in rats. J Neuropathol Exp Neurol 1996; 55(1):106-113. PMID: 8558165 DOI: 10.1097/00005072-199601000-00011
|

Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, Decaux G, Fenske W, Hoorn EJ, Ichai C, Joannidis M, Soupart A, Zietse R, Haller M, van der Veer S, Van Biesen W, Nagler E. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Intensive Care Med 2014; 40(3): 320–331. PMID: 24562549 DOI: 10.1007/s00134-014-3210-2
|

Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH, Thompson CJ. Diagnosis, evaluation, and treatment of hyponatremia: Expert panel recommendations. Am J Med, 2013;126(10 Suppl 1):S1–42. PMID: 24074529 DOI: 10.1016/j.amjmed.2013.07.006
|

Gankam Kengne F, Couturier BS, Soupart A, Decaux G. Urea minimizes brain complications following rapid correction of chronic hyponatremia compared with vasopressin antagonist or hypertonic saline. Kidney Int 2015;87(2): 323–331. PMID: 25100046 DOI: 10.1038/ki.2014.273
|

Bhandari S, Peri A, Cranston I, McCool R, Shaw A, Glanville J, Petrakova L, O’Reilly K. A systematic review of known interventions for the treatment of chronic nonhypovolaemic hypotonic hyponatraemia and a meta-analysis of the vaptans. Clin Endocrinol, 2017;86(6):761–771. PMID: 28214374 doi: 10.1111/cen.13315.
|

Berl T. Vasopressin antagonists. N Engl J Med 2015; 372(23): 2207–2216. PMID: 26039601 DOI: 10.1056/NEJMra1403672
|

Krummel T, Prinz E, Metten M-A, Borni-Duval C, Bazin-Kara D, Charlin E, Lessinger J-M, Hannedouche T. Prognosis of patients with severe hyponatraemia is related not only to hyponatraemia but also to comorbidities and to medical management: results of an observational retrospective study. BMC Nephrol, 2016;17:159. PMCID: PMC5075397 PMID: 27770791 DOI 10.1186/s12882-016-0370-z.
|

Holland-Bill L, Christiansen CF, Heide-Jorgensen U, Ulrichsen SP, Ring T, Jorgensen JO, Sorensen HT. Hyponatremia and mortality risk: a Danish cohort study of 279 508 acutely hospitalized patients. Eur J Endocrinol. 2015;173(1):71–81. PMID: 26036812 DOI: 10.1530/EJE-15-0111
|

Winzeler B, Jeanloz N, Nigro N, Suter-Widmer I, Schuetz P, Arici B, Bally M, Blum C, Bock A, Huber A, Mueller B, Christ-Crain M. Long-term outcome of profound hyponatremia: A prospective 12 months follow-up study. Eur J Endocrinol 2016;175(6): 499–507. DOI: 10.1530/EJE-16-0500
|

McCarthy K, Conway R, Byrne D, Cournane S, O'Riordan D, Silke B. Hyponatraemia during an emergency medical admission as a marker of illness severity & case complexity. European Journal of Internal Medicine, 2019;59:60–64. https://doi.org/10.1016/j.ejim.2018.08.002
|