Останнi рекомендацiї щодо застосування розчинiв гiдроксиетилкрохмалю. Огляд сучасної лiтератури

Автор(и)

  • Ф. С. Глумчер Національний медичний університет імені О.О. Богомольця, Київ, Україна
  • А. М. Сем'янкiв Нацiональний медичний унiверситет iменi О.О. Богомольця, Київ, Україна
  • О. В. Стрепетова Нацiональний медичний унiверситет iменi О.О. Богомольця, Київ, Україна

DOI:

https://doi.org/10.25284/2519-2078.1(66).2014.85614

Ключові слова:

iнфузiйна терапiя, розчини гiдроксиетилкрохмалiв, показання, протипоказання, безпека

Анотація

Iнфузiйна терапiя є важливим компонентом лiкування практично всiх видiв шоку i взагалi iнтенсивної терапiї. У статтi обговорюються основнi проблеми вибору розчинiв для iнфузiйної терапiї. Акцент робиться на застосуваннi розчинiв гiдроксиетилкрохмалiв (ГЕК). Автори наводять короткi iсторичнi данi щодо розчинiв для iнфузiйної терапiї. Розглядають вплив молекулярної ваги розчинiв ГЕК на несприятливi ефекти iнфузiйної терапiї, проводять порiвняння ГЕК з кристалоїдними розчинами, наводять рiзнi данi про безпеку та ефективнiсть ГЕК в порiвняннi з альбумiном та iншими напiвсинтетичними колоїдами. Також наводяться останнi рекомендацiї щодо застосування цих розчинiв у складi iнфузiйної терапiї.

Біографії авторів

Ф. С. Глумчер, Національний медичний університет імені О.О. Богомольця, Київ

Glumcher F.S.

А. М. Сем'янкiв, Нацiональний медичний унiверситет iменi О.О. Богомольця, Київ

Semiankiv A.M.

О. В. Стрепетова, Нацiональний медичний унiверситет iменi О.О. Богомольця, Київ

Strepetova E.V.,

Посилання

Westphal GA. How to guide volume expansion in severe sepsis and septic shock patients? Possibilities in the real world. Shock, 2013;39 Suppl 1:38-41. https://doi.org/10.1097/shk.0b013e31828faf4a

Myburgh JA., Mythen MG. Resuscitation Fluids. N Engl J Med, 2013;369:1243-51. https://doi.org/10.1056/nejmra1208627

Zampieri FG, Park M, Azevedo LC. Colloids in sepsis: evenly distributed molecules surrounded by uneven questions. Shock, 2013;39 Suppl 1:42-9. https://doi.org/10.1097/shk.0b013e31828faf82

Finfer S, Liu B, Taylor C, et al. Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units. Crit Care, 2010;14: R185. https://doi.org/10.1186/cc9293

Van Der Linden P, James M, Mythen M, Weiskopf RB. Safety of modern starches used during surgery. Anesth Analg, 2013;116(1):35-48. https://doi.org/10.1213/ane.0b013e31827175da

Gattas DJ, Dan A, Myburgh J, et al; CHEST Management Committee. Collaborators (18) Fluid resuscitation with 6% hydroxyethyl starch (130/0.4 and 130/0.42) in acutely ill patients: systematic review of effects on mortality and treatment with renal replacement therapy. Intensive Care Med, 2013;39(4):558-68. https://doi.org/10.1007/s00134-013-2840-0

Gillies MA, Habicher M, Jhanji S, et al. Incidence of postoperative death and acute kidney injury associated with i.v. 6% hydroxyethyl starch use: systematic review and meta-analysis. Br J Anaesth, 2014;112(1):25-34. https://doi.org/10.1093/bja/aet303

Brunkhorst FM, Engel C, Bloos F, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med, 2008;358:125-39. https://doi.org/10.1056/nejmoa070716

Patel A, Waheed U, Brett SJ. Randomised trials of 6% tetrastarch (hydroxyethyl starch 130/0.4 or 0.42) for severe sepsis reporting mortality: systematic review and meta-analysis . Intensive Care Med, 2013;39(5):811-22. https://doi.org/10.1007/s00134-013-2863-6

Zarychanski R, Abou-Setta AM, Turgeon AF, et al. Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. JAMA, 2013 20;309(7):678-88. https://doi.org/10.1001/jama.2013.430

Bayer O, Schwarzkopf D, Doenst T, et al. Perioperative Fluid Therapy With Tetrastarch and Gelatin in Cardiac Surgery—A Prospective Sequential Analysis. Crit Care Med, 2013;41(11):2532-42. https://doi.org/10.1097/ccm.0b013e3182978fb6

Brunkhorst FM, Engel C, Bloos F, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med, 2008;358:125-39. https://doi.org/10.1056/nejmoa070716

Kozek-Langenecker SA, Jungheinrich C, et al. The effects of hydroxyethyl starch 130/0.4 (6%) on blood loss and use of blood products in major surgery: a pooled analysis of randomized clinical trials.Anesth Analg, 2008;107(2):382-90. https://doi.org/10.1213/ane.0b013e31817e6eac

Cabrales P, Tsai AG, Intaglietta M. Resuscitation from hemorrhagic shock with hydroxyethyl starch and coagulation changes. Shock, 2007;28(4):461-7. https://doi.org/10.1097/shk.0b013e31804880a1

Simon TP, Schuerholz T, Haugvik SP, et al. High molecular weight hydroxyethyl starch solutions are not more effective than a low wmolecular weight hydroxyethyl starch solution in a porcine model of septic shock. Minerva Anestesiol, 2013;79(1):44-52.

Matharu NM, Butler LM, Rainger GE, et al. Mechanisms of the anti-inflammatory effects of hydroxyethyl starch demonstrated in a flow-based model of neutrophil recruitment by endothelial cells.Crit Care Med, 2008;36(5):1536-42. https://doi.org/10.1097/ccm.0b013e318169f19a

Van Der Linden P, James M, Mythen M, Weiskopf RB. Safety of modern starches used during surgery. Anesth Analg, 2013;116(1):35-48. https://doi.org/10.1213/ane.0b013e31827175da

Zaar M, Lauritzen B, Secher NH. Initial administration of hydroxyethyl starch vs lactated Ringer after liver trauma in the pig. Br J Anaesth, 2009;102(2):221-6. https://doi.org/10.1093/bja/aen350

Myburgh JA, Finfer S, Bellomo R, et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med, 2012;367:1901-11. https://doi.org/10.1056/nejmoa1209759

Inan N, Iltar S, Surer H, Effect of hydroxyethyl starch 130/0.4 on ischaemia/reperfusion in rabbit skeletal muscle. Eur J Anaesthesiol, 2009;26(2):160-50. https://doi.org/10.1097/eja.0b013e32831ac4a7

Kimberger O, Arnberger M, Brandt S, et al. Goal-directed colloid administration improves the microcirculation of healthy and perianastomotic colon. Anesthesiology, 2009;110(3):496-504. https://doi.org/10.1097/aln.0b013e31819841f6

Xiong L, Lei C, Wang Q, Li W. Acute normovolaemic haemodilution with a novel hydroxyethyl starch (130/0.4) reduces focal cerebral ischaemic injury in rats. Eur J Anaesthesiol, 2008;25(7):581-8. https://doi.org/10.1017/s0265021508004067

Kheirabadi BS, Crissey JM, Deguzman R, J et al. Effects of Synthetic Versus Natural Colloid Resuscitation on Inducing Dilutional Coagulopathy and Increasing Hemorrhage in Rabbits // Trauma. 2008;64(5):1218-28. https://doi.org/10.1097/ta.0b013e31816c5c6c

Bayer O, Reinhart K, Sakr Y, et al. Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparison. Crit Care Med, 2011;39:1335-42. https://doi.org/10.1097/ccm.0b013e318212096a

Osthaus WA, Witt L, Johanning K, Boethig D, Equal effects of gelatin and hydroxyethyl starch (6% HES 130/0.42) on modified thrombelastography in children. Acta Anaesthesiol Scand, 2009;53(3):305-10. https://doi.org/10.1111/j.1399-6576.2008.01863.x

Varga R, Török L, Szabó A, et al. Effects of colloid solutions on ischemia-reperfusion-induced periosteal microcirculatory and inflammatory reactions: comparison of dextran, gelatin, and hydroxyethyl starch.Crit Care Med, 2008;36(10):2828-37. https://doi.org/10.1097/ccm.0b013e318186ff48

Godet G, Lehot JJ, Janvier G, et al. Safety of HES 130/0.4 (Voluven®) in patients with preoperative renal dysfunction undergoing abdominal aortic surgery: a prospective, randomized, controlled, parallel-group multicentre trial. Eur J Anaesthesiol, 2008;25(12):986-94. https://doi.org/10.1017/s026502150800447x

Mittermayr M, Streif W, Haas T, et al. Effects of colloid and crystalloid solutions on endogenous activation of fibrinolysis and resistance of polymerized fibrin to recombinant tissue plasminogen activator added ex vivo. Br J Anaesth, 2008;100(3):307-14. https://doi.org/10.1093/bja/aem363

PRAC confirms that hydroxyethyl-starch solutions (HES) should no longer be used in patients with sepsis or burn injuries or in critically ill patients. 11 October 2013 EMA/606303/2013.

Vincent Jean-Louis and De Backer Daniel. Circulatory Shock. N Engl J Med, 2013;369:1726-34. https://doi.org/10.1056/nejmra1208943

##submission.downloads##

Опубліковано

2014-03-24

Як цитувати

Глумчер, Ф. С., Сем’янкiв А. М., & Стрепетова, О. В. (2014). Останнi рекомендацiї щодо застосування розчинiв гiдроксиетилкрохмалю. Огляд сучасної лiтератури. PAIN, ANAESTHESIA & INTENSIVE CARE, (1(66), 68–77. https://doi.org/10.25284/2519-2078.1(66).2014.85614

Номер

Розділ

Статті